Miriplatin-loaded liposome, as a novel mitophagy inducer, suppresses pancreatic cancer proliferation through blocking POLG and TFAM-mediated mtDNA replication

• Asıl Yazarlar: Xiaowei Wang (Yazar), Mengyan Wang (Yazar), Meilian Cai (Yazar), Rongguang Shao (Yazar), Guimin Xia (Yazar), Wuli Zhao (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2023-11-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Pancreatic cancer is a more aggressive and refractory malignancy. Resistance and toxicity limit drug efficacy. Herein, we report a lower toxic and higher effective miriplatin (MPt)-loaded liposome, LMPt, exhibiting totally different anti-cancer mechanism from previously reported platinum agents. Bot...