Miriplatin-loaded liposome, as a novel mitophagy inducer, suppresses pancreatic cancer proliferation through blocking POLG and TFAM-mediated mtDNA replication

Pancreatic cancer is a more aggressive and refractory malignancy. Resistance and toxicity limit drug efficacy. Herein, we report a lower toxic and higher effective miriplatin (MPt)-loaded liposome, LMPt, exhibiting totally different anti-cancer mechanism from previously reported platinum agents. Bot...

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Main Authors: Xiaowei Wang (Author), Mengyan Wang (Author), Meilian Cai (Author), Rongguang Shao (Author), Guimin Xia (Author), Wuli Zhao (Author)
Format: Book
Published: Elsevier, 2023-11-01T00:00:00Z.
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