NLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production.

• Main Authors: Virginia M Gonçalves (Author), Kely C Matteucci (Author), Carina L Buzzo (Author), Bruna H Miollo (Author), Danny Ferrante (Author), Ana C Torrecilhas (Author), Mauricio M Rodrigues (Author), Jose M Alvarez (Author), Karina R Bortoluci (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma cruzi (T. cruzi) is an intracellular protozoan parasite and the etiological agent of Chagas disease, a chronic infectious illness that affects millions of people worldwide. Although the role of TLR and Nod1 in the control of T. cruzi infection is well-established, the involvement of infl...