Exploring somatic mutations in BRAF, KRAS, and NRAS as therapeutic targets in Saudi colorectal cancer patients through massive parallel sequencing and variant classification

• Main Authors: Thamer Abdulhamid Aljuhani (Author), Noor Ahmad Shaik (Author), Rahaf Talal Alqawas (Author), Rana Y. Bokhary (Author), Mahmood Al-Mutadares (Author), Hadiah Bassam Al Mahdi (Author), Nuha Al-Rayes (Author), Ashraf AbdulRahman El-Harouni (Author), Ramu Elango (Author), Babajan Banaganapalli (Author), Zuhier Ahmad Awan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundColorectal cancer (CRC) is the leading cancer among Saudis, and mutations in BRAF, KRAS, and NRAS genes are therapeutically significant due to their association with pathways critical for cell cycle regulation. This study evaluates the prevalence and frequency of somatic mutations in these...