Exploring somatic mutations in BRAF, KRAS, and NRAS as therapeutic targets in Saudi colorectal cancer patients through massive parallel sequencing and variant classification

• मुख्य लेखकों: Thamer Abdulhamid Aljuhani (लेखक), Noor Ahmad Shaik (लेखक), Rahaf Talal Alqawas (लेखक), Rana Y. Bokhary (लेखक), Mahmood Al-Mutadares (लेखक), Hadiah Bassam Al Mahdi (लेखक), Nuha Al-Rayes (लेखक), Ashraf AbdulRahman El-Harouni (लेखक), Ramu Elango (लेखक), Babajan Banaganapalli (लेखक), Zuhier Ahmad Awan (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

BackgroundColorectal cancer (CRC) is the leading cancer among Saudis, and mutations in BRAF, KRAS, and NRAS genes are therapeutically significant due to their association with pathways critical for cell cycle regulation. This study evaluates the prevalence and frequency of somatic mutations in these...