Virtual clinical trial simulations for a novel KRASG12C inhibitor (ASP2453) in non‐small cell lung cancer

• Main Authors: Hiroyuki Sayama (Author), Diana Marcantonio (Author), Takeyuki Nagashima (Author), Masashi Shimazaki (Author), Tsuyoshi Minematsu (Author), Joshua F Apgar (Author), John M. Burke (Author), Lucia Wille (Author), Yasuhisa Nagasaka (Author), Daniel C. Kirouac (Author)
• Format: Book
• Published: Wiley, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract KRAS is a small GTPase family protein that relays extracellular growth signals to cell nucleus. KRASG12C mutations lead to constitutive proliferation signaling and are prevalent across human cancers. ASP2453 is a novel, highly potent, and selective inhibitor of KRASG12C. Although preclinica...