Arecoline suppresses epithelial cell viability by upregulating tropomyosin-1 through the transforming growth factor-β/Smad pathway

• Hauptverfasser: Long Li (Verfasst von), Liqun Gu (Verfasst von), Zhigang Yao (Verfasst von), Yuehong Wang (Verfasst von), Zhangui Tang (Verfasst von), Xiaoying Wu (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Context Oral submucous fibrosis (OSF) is a chronic and progressive disease. Arecoline, present in betel nuts, has been proposed as a vital aetiological factor. However, the underlying mechanism remains unclear. Objectives This research elucidates the expression of tropomyosin-1 (TPM1) and its regula...