Modulation of sleep behavior in zebrafish larvae by pharmacological targeting of the orexin receptor

• Main Authors: Marie Pardon (Author), Pieter Claes (Author), Sarah Druwé (Author), Murielle Martini (Author), Aleksandra Siekierska (Author), Christel Menet (Author), Peter A. M. de Witte (Author), Daniëlle Copmans (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

New pharmacological approaches that target orexin receptors (OXRs) are being developed to treat sleep disorders such as insomnia and narcolepsy, with fewer side effects than existing treatments. Orexins are neuropeptides that exert excitatory effects on postsynaptic neurons via the OXRs, and are imp...