Design, synthesis, and biological screening of a series of 4'-fluoro-benzotriazole-acrylonitrile derivatives as microtubule-destabilising agents (MDAs)

Introduction: Colchicine-binding site inhibitors are some of the most interesting ligands belonging to the wider family of microtubule-destabilising agents.Results: A novel series of 4'-fluoro-substituted ligands (5-13) was synthesised. The antiproliferative activity assays resulted in nM value...

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Main Authors: Federico Riu (Author), Roberta Ibba (Author), Stefano Zoroddu (Author), Simona Sestito (Author), Michele Lai (Author), Sandra Piras (Author), Luca Sanna (Author), Valentina Bordoni (Author), Luigi Bagella (Author), Antonio Carta (Author)
Format: Book
Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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