Design, synthesis, and biological screening of a series of 4'-fluoro-benzotriazole-acrylonitrile derivatives as microtubule-destabilising agents (MDAs)

• मुख्य लेखकों: Federico Riu (लेखक), Roberta Ibba (लेखक), Stefano Zoroddu (लेखक), Simona Sestito (लेखक), Michele Lai (लेखक), Sandra Piras (लेखक), Luca Sanna (लेखक), Valentina Bordoni (लेखक), Luigi Bagella (लेखक), Antonio Carta (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Introduction: Colchicine-binding site inhibitors are some of the most interesting ligands belonging to the wider family of microtubule-destabilising agents.Results: A novel series of 4'-fluoro-substituted ligands (5-13) was synthesised. The antiproliferative activity assays resulted in nM value...