Design, synthesis, and biological screening of a series of 4'-fluoro-benzotriazole-acrylonitrile derivatives as microtubule-destabilising agents (MDAs)

• Asıl Yazarlar: Federico Riu (Yazar), Roberta Ibba (Yazar), Stefano Zoroddu (Yazar), Simona Sestito (Yazar), Michele Lai (Yazar), Sandra Piras (Yazar), Luca Sanna (Yazar), Valentina Bordoni (Yazar), Luigi Bagella (Yazar), Antonio Carta (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Introduction: Colchicine-binding site inhibitors are some of the most interesting ligands belonging to the wider family of microtubule-destabilising agents.Results: A novel series of 4'-fluoro-substituted ligands (5-13) was synthesised. The antiproliferative activity assays resulted in nM value...