Design, synthesis, and biological screening of a series of 4'-fluoro-benzotriazole-acrylonitrile derivatives as microtubule-destabilising agents (MDAs)

• Váldodahkkit: Federico Riu (Dahkki), Roberta Ibba (Dahkki), Stefano Zoroddu (Dahkki), Simona Sestito (Dahkki), Michele Lai (Dahkki), Sandra Piras (Dahkki), Luca Sanna (Dahkki), Valentina Bordoni (Dahkki), Luigi Bagella (Dahkki), Antonio Carta (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Introduction: Colchicine-binding site inhibitors are some of the most interesting ligands belonging to the wider family of microtubule-destabilising agents.Results: A novel series of 4'-fluoro-substituted ligands (5-13) was synthesised. The antiproliferative activity assays resulted in nM value...