SARS-CoV-2 Switches 'on' MAPK and NFκB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression

• Main Authors: Swati Goel (Author), Fatemeh Saheb Sharif-Askari (Author), Narjes Saheb Sharif Askari (Author), Bushra Madkhana (Author), Ahmad Munzer Alwaa (Author), Bassam Mahboub (Author), Adel M Zakeri (Author), Elaref Ratemi (Author), Rifat Hamoudi (Author), Qutayba Hamid (Author), Rabih Halwani (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitogen-activated protein kinases (MAPK) and NF-kappaB (NF-κB) pathway regulate many cellular processes and are essential for immune cells function. Their activity is controlled by dual-specificity phosphatases (DUSPs). A comprehensive analysis of publicly available gene expression data sets of huma...