The effect of monosialylganglioside mix modifying the PEGylated liposomal epirubicin on the accelerated blood clearance phenomenon

• Principais autores: Ting Zhang (Autor), Songlei Zhou (Autor), Le Kang (Autor), Xiang Luo (Autor), Yang Liu (Autor), Yanzhi Song (Autor), Xinrong Liu (Autor), Yihui Deng (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2017-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

PEGylated liposomes are potential candidates to improve the pharmacokinetic characteristics of encapsulated drugs, to extend their circulation half-life and facilitate their passive accumulation at tumour sites. However, PEG-modified liposomes can induce accelerated blood clearance (ABC) upon repeat...