The effect of monosialylganglioside mix modifying the PEGylated liposomal epirubicin on the accelerated blood clearance phenomenon

• Main Authors: Ting Zhang (Author), Songlei Zhou (Author), Le Kang (Author), Xiang Luo (Author), Yang Liu (Author), Yanzhi Song (Author), Xinrong Liu (Author), Yihui Deng (Author)
• Format: Book
• Published: Elsevier, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PEGylated liposomes are potential candidates to improve the pharmacokinetic characteristics of encapsulated drugs, to extend their circulation half-life and facilitate their passive accumulation at tumour sites. However, PEG-modified liposomes can induce accelerated blood clearance (ABC) upon repeat...