Anti-inflammatory effect of a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor via the stimulation of heme oxygenase-1 in LPS-activated mice and J774.1 murine macrophages

• Main Authors: Sung Bum Park (Author), Ji Seon Park (Author), Won Hoon Jung (Author), Hee Youn Kim (Author), Hyun Jung Kwak (Author), Jin Hee Ahn (Author), Kyoung-Jin Choi (Author), Yoon-Ju Na (Author), Sunhwa Choi (Author), Sang Dal Rhee (Author), Ki Young Kim (Author)
• Format: Book
• Published: Elsevier, 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts inactive cortisone to the active cortisol. 11β-HSD1 may be involved in the resolution of inflammation. In the present study, we investigate the anti-inflammatory effects of 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-pheny...