The role of PIK3CA gene mutations in colorectal cancer and the selection of treatment strategies
PIK3CA gene encodes the p110α catalytic subunit of PI3K, which regulates the PI3K/AKT/mTOR signaling pathway. PIK3CA gene mutation is one of the most common mutations in colorectal cancer (CRC), affecting about 15%-20% of CRC patients. PIK3CA gene mutation leads to the persistent activation of the P...
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Frontiers Media S.A.,
2024-10-01T00:00:00Z.
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