The role of PIK3CA gene mutations in colorectal cancer and the selection of treatment strategies

• Main Authors: Haitao Wang (Author), Rui Tang (Author), Ling Jiang (Author), Yingtian Jia (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

PIK3CA gene encodes the p110α catalytic subunit of PI3K, which regulates the PI3K/AKT/mTOR signaling pathway. PIK3CA gene mutation is one of the most common mutations in colorectal cancer (CRC), affecting about 15%-20% of CRC patients. PIK3CA gene mutation leads to the persistent activation of the P...