Shenzhi Jiannao formula ameliorates vascular dementia in vivo and in vitro by inhibition glutamate neurotoxicity via promoting clathrin-mediated endocytosis

• Główni autorzy: Danfeng Tian (Autor), Yangyang Guo (Autor), Dandan Zhang (Autor), Qiang Gao (Autor), Ganlu Liu (Autor), Jingfeng Lin (Autor), Ze Chang (Autor), Yuchun Wang (Autor), Rui Su (Autor), Zhenyun Han (Autor)
• Format: Książka
• Wydane: BMC, 2021-07-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Abstract Background Synaptic damage and glutamate excitotoxicity have been implicated in the pathogenesis of vascular dementia (VD). Clathrin, RAB5B and N-methyl-d-aspartic acid receptor 1 (NMDAR1) proteins play a vital role in endocytosis of synaptic vesicles in neurons and glutamate over accumulat...