Shenzhi Jiannao formula ameliorates vascular dementia in vivo and in vitro by inhibition glutamate neurotoxicity via promoting clathrin-mediated endocytosis

• Main Authors: Danfeng Tian (Author), Yangyang Guo (Author), Dandan Zhang (Author), Qiang Gao (Author), Ganlu Liu (Author), Jingfeng Lin (Author), Ze Chang (Author), Yuchun Wang (Author), Rui Su (Author), Zhenyun Han (Author)
• Format: Book
• Published: BMC, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Synaptic damage and glutamate excitotoxicity have been implicated in the pathogenesis of vascular dementia (VD). Clathrin, RAB5B and N-methyl-d-aspartic acid receptor 1 (NMDAR1) proteins play a vital role in endocytosis of synaptic vesicles in neurons and glutamate over accumulat...