The extrahepatic role of TFR2 in iron homeostasis

• Main Authors: Laura eSilvestri (Author), Antonella eNai (Author), Alessia ePagani (Author), Clara eCamaschella (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transferrin receptor 2 (TFR2), a protein homologous to the cell iron importer transferrin receptor 1 (TFR1), is expressed in the liver and erythroid cells and is reported to bind diferric transferrin, although at lower affinity than TFR1. TFR2 gene is mutated in type 3 hemochromatosis, a disorder ch...