Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system

• Main Authors: Kaijian Ling (Author), Lupin Jiang (Author), Shi Liang (Author), Joseph Kwong (Author), Leiyan Yang (Author), Yudi Li (Author), PingYin (Author), Qingchun Deng (Author), Zhiqing Liang (Author)
• Format: Book
• Published: BMC, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ovarian cancer stem cells (OCSCs) contribute to the poor prognosis of ovarian cancer. Involvement of the androgen receptor (AR) in the malignant behaviors of other tumors has been reported. However, whether AR associates with Nanog (a stem cell marker) and participates in OCSC fu...