Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells

• Main Authors: Rachel S. Fletcher (Author), Joanna Ratajczak (Author), Craig L. Doig (Author), Lucy A. Oakey (Author), Rebecca Callingham (Author), Gabriella Da Silva Xavier (Author), Antje Garten (Author), Yasir S. Elhassan (Author), Philip Redpath (Author), Marie E. Migaud (Author), Andrew Philp (Author), Charles Brenner (Author), Carles Canto (Author), Gareth G. Lavery (Author)
• Format: Book
• Published: Elsevier, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Augmenting nicotinamide adenine dinucleotide (NAD+) availability may protect skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) appear efficacious in elevating muscle NAD+. Here we...