Predicting capsule fill weight from in-situ powder density measurements using terahertz reflection technology

• Main Authors: Sandra Stranzinger (Author), Eva Faulhammer (Author), Jingyi Li (Author), Runqiao Dong (Author), J. Axel Zeitler (Author), Stefano Biserni (Author), Vittorio Calzolari (Author), Johannes G. Khinast (Author), Daniel Markl (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The manufacturing of the majority of solid oral dosage forms is based on the densification of powder. A good understanding of the powder behavior is therefore essential to assure high quality drug products. This is particularly relevant for the capsule filling process, where the powder bulk density...