Fitness impact and stability of a transgene conferring resistance to dengue-2 virus following introgression into a genetically diverse Aedes aegypti strain.

• Egile Nagusiak: Alexander W E Franz (Egilea), Irma Sanchez-Vargas (Egilea), Robyn R Raban (Egilea), William C Black (Egilea), Anthony A James (Egilea), Ken E Olson (Egilea)
• Formatua: Liburua
• Argitaratua: Public Library of Science (PLoS), 2014-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

In 2006, we reported a mariner (Mos1)-transformed Aedes aegypti line, Carb77, which was highly resistant to dengue-2 virus (DENV2). Carb77 mosquitoes expressed a DENV2-specific inverted-repeat (IR) RNA in midgut epithelial cells after ingesting an infectious bloodmeal. The IR-RNA formed double-stran...