In vitro evaluation of sustained released matrix tablets containing ibuprofen: a model poorly water-soluble drug

• Main Authors: Wendy Leticia Guerra-Ponce (Author), Sandra Leticia Gracia-Vásquez (Author), Patricia González-Barranco (Author), Ivonne Antonieta Camacho-Mora (Author), Yolanda Araceli Gracia-Vásquez (Author), Elizabeth Orozco-Beltrán (Author), Linda Anne Felton (Author)
• Format: Book
• Published: Universidade de São Paulo.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT A matrix system was developed that releases ibuprofen (IB) over a 12-hour period and the influence of the polymer type and concentration on the release rate of the drug was evaluated. Tablets containing different concentrations of Carbopol (CP), hydroxypropyl methylcellulose (HPMC), or ethy...