Design of Diarylheptanoid Derivatives as Dual Inhibitors Against Class IIa Histone Deacetylase and β-amyloid Aggregation

• Main Authors: Liang-Chieh Chen (Author), Hui-Ju Tseng (Author), Chang-Yi Liu (Author), Yun-Yi Huang (Author), Cheng-Chung Yen (Author), Jing-Ru Weng (Author), Yeh-Lin Lu (Author), Wen-Chi Hou (Author), Tony E. Lin (Author), I-Horng Pan (Author), Kuo-Kuei Huang (Author), Wei-Jan Huang (Author), Kai-Cheng Hsu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with multiple etiologies. Beta-amyloid (Aβ) self-aggregation and overexpression of class IIa histone deacetylases (HDACs) are strongly implicated with AD pathogenesis. In this study, a series of novel diarylheptanoid derivativ...