Design of Diarylheptanoid Derivatives as Dual Inhibitors Against Class IIa Histone Deacetylase and β-amyloid Aggregation

• Автори: Liang-Chieh Chen (Автор), Hui-Ju Tseng (Автор), Chang-Yi Liu (Автор), Yun-Yi Huang (Автор), Cheng-Chung Yen (Автор), Jing-Ru Weng (Автор), Yeh-Lin Lu (Автор), Wen-Chi Hou (Автор), Tony E. Lin (Автор), I-Horng Pan (Автор), Kuo-Kuei Huang (Автор), Wei-Jan Huang (Автор), Kai-Cheng Hsu (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with multiple etiologies. Beta-amyloid (Aβ) self-aggregation and overexpression of class IIa histone deacetylases (HDACs) are strongly implicated with AD pathogenesis. In this study, a series of novel diarylheptanoid derivativ...