Inhibition of cholinergic potentiation of insulin secretion from pancreatic islets by chronic elevation of glucose and fatty acids: Protection by casein kinase 2 inhibitor

• Główni autorzy: Nicolai M. Doliba (Autor), Qin Liu (Autor), Changhong Li (Autor), Pan Chen (Autor), Chengyang Liu (Autor), Ali Naji (Autor), Franz M. Matschinsky (Autor)
• Format: Książka
• Wydane: Elsevier, 2017-10-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Objectives: Chronic hyperlipidemia and hyperglycemia are characteristic features of type 2 diabetes (T2DM) that are thought to cause or contribute to β-cell dysfunction by "glucolipotoxicity." Previously we have shown that acute treatment of pancreatic islets with fatty acids (FA) decrease...