Inhibition of cholinergic potentiation of insulin secretion from pancreatic islets by chronic elevation of glucose and fatty acids: Protection by casein kinase 2 inhibitor

• Autori principali: Nicolai M. Doliba (Autore), Qin Liu (Autore), Changhong Li (Autore), Pan Chen (Autore), Chengyang Liu (Autore), Ali Naji (Autore), Franz M. Matschinsky (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2017-10-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Objectives: Chronic hyperlipidemia and hyperglycemia are characteristic features of type 2 diabetes (T2DM) that are thought to cause or contribute to β-cell dysfunction by "glucolipotoxicity." Previously we have shown that acute treatment of pancreatic islets with fatty acids (FA) decrease...