Inhibition of cholinergic potentiation of insulin secretion from pancreatic islets by chronic elevation of glucose and fatty acids: Protection by casein kinase 2 inhibitor

• Egile Nagusiak: Nicolai M. Doliba (Egilea), Qin Liu (Egilea), Changhong Li (Egilea), Pan Chen (Egilea), Chengyang Liu (Egilea), Ali Naji (Egilea), Franz M. Matschinsky (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2017-10-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Objectives: Chronic hyperlipidemia and hyperglycemia are characteristic features of type 2 diabetes (T2DM) that are thought to cause or contribute to β-cell dysfunction by "glucolipotoxicity." Previously we have shown that acute treatment of pancreatic islets with fatty acids (FA) decrease...