The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury

• Principais autores: Francesca V. LoBianco (Autor), Kimberly J. Krager (Autor), Gwendolyn S. Carter (Autor), Sinthia Alam (Autor), Youzhong Yuan (Autor), Elise G. Lavoie (Autor), Jonathan A. Dranoff (Autor), Nukhet Aykin-Burns (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2020-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

In patients with abdominal region cancers, ionizing radiation (IR)-induced long-term liver injury is a major limiting factor in the use of radiotherapy. Previously, the major mitochondrial deacetylase, sirtuin 3 (SIRT3), has been implicated to play an important role in the development of acute liver...