The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury

• Main Authors: Francesca V. LoBianco (Author), Kimberly J. Krager (Author), Gwendolyn S. Carter (Author), Sinthia Alam (Author), Youzhong Yuan (Author), Elise G. Lavoie (Author), Jonathan A. Dranoff (Author), Nukhet Aykin-Burns (Author)
• Format: Book
• Published: MDPI AG, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In patients with abdominal region cancers, ionizing radiation (IR)-induced long-term liver injury is a major limiting factor in the use of radiotherapy. Previously, the major mitochondrial deacetylase, sirtuin 3 (SIRT3), has been implicated to play an important role in the development of acute liver...