Tadalafil, a Long-Acting Inhibitor of PDE5, Improves Pulmonary Hemodynamics and Survival Rate of Monocrotaline-Induced Pulmonary Artery Hypertension in Rats

• Prif Awduron: Fusae Sawamura (Awdur), Masami Kato (Awdur), Kazuhisa Fujita (Awdur), Takahiro Nakazawa (Awdur), Anthony Beardsworth (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Elsevier, 2009-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

The aim of this study was to assess the effect of tadalafil (0.5, 2.5, and 10 mg/kg per day) on the progression of pulmonary arterial hypertension (PAH) in early treatment and on the survival rate in late treatment on the monocrotaline (MCT)-induced PAH rat model. Tadalafil was administered once dai...