The Core-Targeted RRM2 Gene of Berberine Hydrochloride Promotes Breast Cancer Cell Migration and Invasion via the Epithelial-Mesenchymal Transition

• Main Authors: Jiaming He (Author), Qiang Wei (Author), Rong Jiang (Author), Tiankuo Luan (Author), Shuang He (Author), Ruijin Lu (Author), Hang Xu (Author), Jianhua Ran (Author), Jing Li (Author), Dilong Chen (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Berberine hydrochloride (BBR) could inhibit the proliferation, migration, and invasion of various cancer cells. As the only enzyme for the de novo synthesis of ribonucleotides, RRM2 is closely related to the development of tumorigenesis. However, not much is currently known about the functional role...