Eph A10-modified pH-sensitive liposomes loaded with novel triphenylphosphine-docetaxel conjugate possess hierarchical targetability and sufficient antitumor effect both in vitro and in vivo

• Main Authors: Jiulong Zhang (Author), Chunrong Yang (Author), Shuang Pan (Author), Menghao Shi (Author), Jie Li (Author), Haiyang Hu (Author), Mingxi Qiao (Author), Dawei Chen (Author), Xiuli Zhao (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial-targeting therapy was considered to be a promising approach for the efficient treatment of cancer while positive charge induced nonspecific cytotoxicity severely limits its application. To overcome this drawback, a novel mitochondria targeted conjugate triphenylphosphine-docetaxel (TD)...