Developmental Changes in Excitation-Contraction Mechanisms of the Mouse Ventricular Myocardium as Revealed by Functional and Confocal Imaging Analyses

• Main Authors: Shogo Hamaguchi (Author), Yuko Kawakami (Author), Yoriko Honda (Author), Kana Nemoto (Author), Ayaka Sano (Author), Iyuki Namekata (Author), Hikaru Tanaka (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Developmental changes in excitation-contraction mechanisms were examined in the ventricular myocardium from fetal, neonatal, and 1-, 2-, and 4-week-old mice. In isolated tissue, the negative inotropic effect of nifedipine decreased, while that of ryanodine increased with age. Action potential durati...