Assessing the activity of nonsense-mediated mRNA decay in lung cancer

• Main Authors: Meng Wang (Author), Peiwei Zhang (Author), Yufei Zhu (Author), Xiangyin Kong (Author), Zhenguo Zhang (Author), Landian Hu (Author)
• Formato: Livro
• Publicado em: BMC, 2017-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background Inhibition of nonsense-mediated mRNA decay (NMD) in tumor cells can suppress tumor growth through expressing new antigens whose mRNAs otherwise are degraded by NMD. Thus NMD inhibition is a promising approach for developing cancer therapies. Apparently, the success of this approa...