Evaluation of the influence of fluoroquinolone chemical structure on stability: forced degradation and in silico studies

• Main Authors: André Valle de Bairros (Author), Danillo Baptista Pereira (Author), Everson Willian Fialho Cordeiro (Author), Clésio Soldateli Paim (Author), Fabiana Ernestina Barcellos da Silva (Author), Marcelo Donadel Malesuik (Author), Fávero Reisdorfer Paula (Author)
• Format: Book
• Published: Universidade de São Paulo, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT Fluoroquinolones are a known antibacterial class commonly used around the world. These compounds present relative stability and they may show some adverse effects according their distinct chemical structures. The chemical hydrolysis of five fluoroquinolones was studied using alkaline and ph...