Differential regulation of the unfolded protein response in outbred deer mice and susceptibility to metabolic disease

• Ngā kaituhi matua: Amanda Havighorst (Author), Youwen Zhang (Author), Elena Farmaki (Author), Vimala Kaza (Author), Ioulia Chatzistamou (Author), Hippokratis Kiaris (Author)
• Hōputu: Pukapuka
• I whakaputaina: The Company of Biologists, 2019-02-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Endoplasmic reticulum (ER) stress has been causatively linked to the onset of various pathologies. However, whether and how inherent variations in the resulting unfolded protein response (UPR) affect predisposition to ER-stress-associated metabolic conditions remains to be established. By using gene...