Targeting Lactate Dehydrogenase-B as a Strategy to Fight Cancer: Identification of Potential Inhibitors by In Silico Analysis and In Vitro Screening

• Главные авторы: Manos Vlasiou (Автор), Vicky Nicolaidou (Автор), Christos Papaneophytou (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2023-10-01T00:00:00Z.
• Предметы: article
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Lactate dehydrogenase (LDH) is an enzyme that catalyzes the reversible conversion of lactate to pyruvate while reducing NAD⁺ to NADH (or oxidizing NADH to NAD⁺). Due to its central role in the Warburg effect, LDH-A isoform has been considered a promising...