Targeting Lactate Dehydrogenase-B as a Strategy to Fight Cancer: Identification of Potential Inhibitors by In Silico Analysis and In Vitro Screening

• Main Authors: Manos Vlasiou (Author), Vicky Nicolaidou (Author), Christos Papaneophytou (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2023-10-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Lactate dehydrogenase (LDH) is an enzyme that catalyzes the reversible conversion of lactate to pyruvate while reducing NAD⁺ to NADH (or oxidizing NADH to NAD⁺). Due to its central role in the Warburg effect, LDH-A isoform has been considered a promising...