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A semimechanistic population pharmacokinetic and pharmacodynamic model incorporating autoinduction for the dose justification of TAS‐114

Abstract TAS‐114 is a dual deoxyuridine triphosphatase (dUTPase) and dihydropyrimidine dehydrogenase (DPD) inhibitor expected to widen the therapeutic index of capecitabine. Its maximum tolerated dose (MTD) was determined from a safety perspective in a combination study with capecitabine; however, i...

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Prif Awduron:	Hikari Araki (Awdur), Toru Takenaka (Awdur), Koichi Takahashi (Awdur), Fumiaki Yamashita (Awdur), Kazuaki Matsuoka (Awdur), Kunihiro Yoshisue (Awdur), Ichiro Ieiri (Awdur)
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Cyhoeddwyd:	Wiley, 2022-05-01T00:00:00Z.
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