A semimechanistic population pharmacokinetic and pharmacodynamic model incorporating autoinduction for the dose justification of TAS‐114
Abstract TAS‐114 is a dual deoxyuridine triphosphatase (dUTPase) and dihydropyrimidine dehydrogenase (DPD) inhibitor expected to widen the therapeutic index of capecitabine. Its maximum tolerated dose (MTD) was determined from a safety perspective in a combination study with capecitabine; however, i...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
Wiley,
2022-05-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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