The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo

• Main Authors: Su-Ru Lin (Author), Hung-Chih Yang (Author), Yi-Ting Kuo (Author), Chun-Jen Liu (Author), Ta-Yu Yang (Author), Ku-Chun Sung (Author), You-Yu Lin (Author), Hurng-Yi Wang (Author), Chih-Chiang Wang (Author), Yueh-Chi Shen (Author), Fang-Yi Wu (Author), Jia-Horng Kao (Author), Ding-Shinn Chen (Author), Pei-Jer Chen (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Persistence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) under current antiviral therapy is a major barrier to eradication of chronic hepatitis B (CHB). Curing CHB will require novel strategies for specific disruption of cccDNA. The clustered regularly interspaced short palindr...