The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo
Persistence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) under current antiviral therapy is a major barrier to eradication of chronic hepatitis B (CHB). Curing CHB will require novel strategies for specific disruption of cccDNA. The clustered regularly interspaced short palindr...
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Elsevier,
2014-01-01T00:00:00Z.
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