Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control

• Main Authors: Yang Jiang (Author), Adam J. Rose (Author), Tjeerd P. Sijmonsma (Author), Angelika Bröer (Author), Anja Pfenninger (Author), Stephan Herzig (Author), Dieter Schmoll (Author), Stefan Bröer (Author)
• Format: Book
• Published: Elsevier, 2015-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Type 2 diabetes arises from insulin resistance of peripheral tissues followed by dysfunction of β-cells in the pancreas due to metabolic stress. Both depletion and supplementation of neutral amino acids have been discussed as strategies to improve insulin sensitivity. Here we characterise...