Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control

• Egile Nagusiak: Yang Jiang (Egilea), Adam J. Rose (Egilea), Tjeerd P. Sijmonsma (Egilea), Angelika Bröer (Egilea), Anja Pfenninger (Egilea), Stephan Herzig (Egilea), Dieter Schmoll (Egilea), Stefan Bröer (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2015-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Objective: Type 2 diabetes arises from insulin resistance of peripheral tissues followed by dysfunction of β-cells in the pancreas due to metabolic stress. Both depletion and supplementation of neutral amino acids have been discussed as strategies to improve insulin sensitivity. Here we characterise...