<i>CYP3A5*3</i> and <i>SLCO1B1</i> c.521T>C Polymorphisms Influence the Pharmacokinetics of Atorvastatin and 2-Hydroxy Atorvastatin

• Main Authors: Jin-Woo Park (Author), Jong-Min Kim (Author), Hwa-Young Lee (Author), Jihyeon Noh (Author), Kyoung-Ah Kim (Author), Ji-Young Park (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is a large variability in individual responses to atorvastatin administration. This study assessed the pharmacogenetic effects of solute carrier organic anion transporter family member 1B1 (<i>SLCO1B1</i>, c.388A>G and c.521T>C) and cytochrome P450 3A5 (<i>CYP3A5</i&...