SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy

• Main Authors: Zhenzhen Li (Author), Xiaoying Zhang (Author), Zhen Guo (Author), Yao Zhong (Author), Panxia Wang (Author), Jingyan Li (Author), Zhuoming Li (Author), Peiqing Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NFATc4, a member from the Nuclear Factor of Activated T cells (NFATs) transcription factor family, plays a pivotal role in the development of cardiac hypertrophy. NFATc4 is dephosphorylated by calcineurin and translocated from the cytoplasm to the nucleus to regulate the expression of hypertrophic g...