Overcoming the Undesirable CRISPR-Cas9 Expression in Gene Correction

• Main Authors: Emily Xia (Author), Rongqi Duan (Author), Fushan Shi (Author), Kyle E. Seigel (Author), Hartmut Grasemann (Author), Jim Hu (Author)
• Formato: Libro
• Publicado: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

The CRISPR-Cas9 system is attractive for gene therapy, as it allows for permanent genetic correction. However, as a new technology, Cas9 gene editing in clinical applications faces major challenges, such as safe delivery and gene targeting efficiency. Cas9 is a foreign protein to recipient cells; th...