Overcoming the Undesirable CRISPR-Cas9 Expression in Gene Correction

• Главные авторы: Emily Xia (Автор), Rongqi Duan (Автор), Fushan Shi (Автор), Kyle E. Seigel (Автор), Hartmut Grasemann (Автор), Jim Hu (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2018-12-01T00:00:00Z.
• Предметы: article
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The CRISPR-Cas9 system is attractive for gene therapy, as it allows for permanent genetic correction. However, as a new technology, Cas9 gene editing in clinical applications faces major challenges, such as safe delivery and gene targeting efficiency. Cas9 is a foreign protein to recipient cells; th...