Different Pharmacokinetics of Tramadol, O-Demethyltramadol and N-Demethyltramadol in Postoperative Surgical Patients From Those Observed in Medical Patients

• Auteurs principaux: Nenad Neskovic (Auteur), Dario Mandic (Auteur), Saska Marczi (Auteur), Sonja Skiljic (Auteur), Gordana Kristek (Auteur), Hrvoje Vinkovic (Auteur), Boris Mraovic (Auteur), Zeljko Debeljak (Auteur), Slavica Kvolik (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Background: Most studies examining tramadol metabolism have been carried out in non-surgical patients and with oral tramadol. The aim of this study was 1) to measure concentrations of tramadol, O-demethyltramadol (ODT), and N-demethyltramadol (NDT) in the surgical patients admitted to the intensive...