Different Pharmacokinetics of Tramadol, O-Demethyltramadol and N-Demethyltramadol in Postoperative Surgical Patients From Those Observed in Medical Patients

• Main Authors: Nenad Neskovic (Author), Dario Mandic (Author), Saska Marczi (Author), Sonja Skiljic (Author), Gordana Kristek (Author), Hrvoje Vinkovic (Author), Boris Mraovic (Author), Zeljko Debeljak (Author), Slavica Kvolik (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Most studies examining tramadol metabolism have been carried out in non-surgical patients and with oral tramadol. The aim of this study was 1) to measure concentrations of tramadol, O-demethyltramadol (ODT), and N-demethyltramadol (NDT) in the surgical patients admitted to the intensive...